Chondroitin sulfate along with glucosamine are among the most popular supplements for arthritis. Chondroitin sulfate is normally found in cartilage tissue as a glycosaminoglycan (GAG). In cartilage it is normally attached to protein and gives cartilage its resistance to compression.
Studies have yielded mixed results with some claiming that chondroitin sulfate supplementation results in joint space narrowing from increased cartilage synthesis1 and the recent Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) finding that patients taking chondroitin sulfate were noted to have a statistically significant improvement in knee joint swelling.2
1https://www.sciencedirect.com/science/article/pii/S106345840400007X
2https://www.sciencedirect.com/science/article/pii/S1063458408002045
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